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Abstract

The invention provides compounds of formula (I) 1 wherein A and B represent the groups CH.sub.2).sub.m-- and CH.sub.2).sub.n--respectively; R.sup.1 represents hydrogen or C.sub.1-4alkyl; R.sup.2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC.sub.1-6alkyl, trifluoromethyl, trifluoromethoxy, C.sub.1-6alkyl, C.sub.1-6alkoxy, --(CH.sub.2).sub.pC.sub.3-6cycloalkyl, --(CH.sub.2).sub.pC.sub.3-6cycloalkyloxy, --COC.sub.1-6alkyl, --SO.sub.2C.sub.1-6alkyl, --SOC.sub.1-6alkyl, --S-C.sub.1-6alkyl, --CO.sub.2C.sub.1-6alkyl, --CO.sub.2NR.sup.7R.sup.8, --SO.sub.2NR.sup.7R.sup.8, --(CH.sub.2).sub.pNR.sup.7R.sup.8, --(CH.sub.2).sub.pNR.sup.7COR.sup.8, optionally substituted aryl, optionally substituted heteroaryl or a fused bicyclic heterocyclic ring system; R.sup.3 represents hydrogen or C.sub.1-6alkyl; R.sup.4 represents halogen, trifluoromethyl, trifluoromethoxy, C.sub.1-6alkyl, C.sub.1-6alkoxy, --(CH.sub.2).sub.pC.sub.3-6cycloalkyl or --(CH.sub.2).sub.pC.sub.3-6cycloalkyloxy; R.sup.5 and R.sup.6 each independently represent hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC.sub.1-6alkyl, trifluoromethyl, trifluoromethoxy, C.sub.1-6alkyl, C.sub.1-6alkoxy, --(CH.sub.2).sub.pC.sub.3-6cycloalkyl, --(CH.sub.2).sub.pC.sub.3-6cycloal-kyloxy, --COC.sub.1-6alkyl, --SO.sub.2C.sub.1-6alkyl, --SOC.sub.1-6alkyl, --S--C.sub.1-6alkyl, --CO.sub.2C.sub.1-6alkyl, --CO.sub.2NR.sup.7R.sup.8, --SO.sub.2NR.sup.7R.sup.8, --(CH.sub.2).sub.pNR.sup.7R.sup.8, --(CH.sub.2).sub.pNR.sup.7COR.sup.8, optionally substituted aryl, optionally substituted heteroaryl or a fused bicyclic heterocyclic ring system; R.sup.7 and R.sup.8 each independently represent hydrogen or C.sub.1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that the compounds 4-methyl-N-(1,2,3,4-tetrahydroisoquino-lin-6-yl)-benzenesulfonamide, 7-(4-chlorophenyl)sulfonamido-1,2,3,4-tetrah-ydroisoquinoline hydrochloride and N-(2-ethyl-5-isoindolinyl)-p-toluenesul-fonamide are excluded. The compounds are useful in therapy, in particular as antipsychotic agents.

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First Claim