Acid-sensitive compounds, preparation and use thereof
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United States of America Patent
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Issued Date -
Apr 21, 2005
app pub date -
Sep 10, 2004
filing date -
Sep 5, 2000
priority date (Note) -
Abandoned
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Abstract
Novel acid-sensitive compounds comprising at least one hydrophilic substituent and a cyclic ortho-ester which is acid-sensitive, and their salts. These compounds are useful for forming conjugates (liposomes, complexes, nanoparticles and the like) with biologically active substances and releasing them into cellular tissues or compartments whose pH is acidic, or as nonionic surfactant for stabilizing particles encapsulating a biologically active substance and then destabilizing them in acid medium, or alternatively as a vector covalently linked to a therapeutic molecule so as to release said therapeutic molecule into the cellular tissues or compartments whose pH is acidic.
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