Tridimensional biocompatible support structure for bioartificial organs and uses thereof
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United States of America Patent
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app pub date -
Oct 21, 2003
filing date -
May 1, 2001
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Abandoned
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Abstract
The present invention relates to a biocompatible support structure for culturing cells in three dimensions. In a preferred embodiment, the support structure is constituted essentially of cross-linked polyvinylalcohol (PVA). More preferably, the matrix has the form of a sponge and is used for the culture of hepatocytes. The invention also relates to methods of manufacturing such structure and to methods of using the same in vitro, ex vivo as well as in vivo. The invention further relates to a bioartificial organ and to a tridimensional cell culture system which may be used for the production of therapeutic proteins, used as a detoxification device, used as a tool in predictive toxicology of compounds in the pharmaceutical industry and/or used for transplantation.
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