Condensed heterocyclic compounds
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United States of America Patent
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Issued Date -
Apr 14, 2005
app pub date -
Jul 23, 2004
filing date -
Jan 29, 2002
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Abandoned
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Abstract
A condensed heterocyclic compound having poly(adenosine 5'-diphospho-ribose)polymerase (PARP) inhibitory activity by the formula (I): wherein R.sup.1 is hydrogen, halogen, lower alkyl or lower alkoxy, A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, pyridine ring, etc, --Y.sup.1.dbd.Y.sup.2-- is formula (II) wherein L.sup.11, L.sup.12, L.sup.13 and L.sup.14 is (1) lower alkylene, (2) lower alkenylene, etc, and R.sup.21, R.sup.22, R.sup.23 and R.sup.24 is (1) cyclic amino group, which is substituted with phenyl optionally substituted with one or more suitable substituent(s), etc. provided that when A and two adjacent carbon atoms of the six membered ring to be bonded with A form benzene ring, then --Y.sup.1.dbd.Y.sup.2-- is formula (III) or its prodrug, or their salts. 1
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