Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
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United States of America Patent
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Issued Date -
Apr 7, 2005
app pub date -
Jun 18, 2004
filing date -
Jul 1, 2003
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Abandoned
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Abstract
This invention provides compounds of Formula I, including pharmaceutically accceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula 1 wherein: Z is 2 Q is selected from the group consisting of 3 m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and --W-- is 4
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