Production of infectious hepadnavirus particles containing foamy retrovirus envelope proteins and methods of using the same
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United States of America Patent
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Issued Date -
Apr 7, 2005
app pub date -
Nov 25, 2003
filing date -
Jun 21, 2001
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Abandoned
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Abstract
The invention provides a method for producing a hepadnavirus virion that is infectious in vitro which comprises:(a) introducing into a cell (i) a hepadnavirus genome expression vector and (ii) a foamy retrovirus envelope expression vector which comprises a nucleic acid encoding at least a fragment of a foamy virus envelope protein, and (b) culturing the cell thereby producing hepadnavirus virions comprising at least a fragment of a foamy virus envelope protein, wherein the hepadnavirus virions are infectious in vitro. A method for determining susceptibility for an anti-hepadnavirus drug, a method for determining replication capacity of a hepadnavirus from an infected patient, and method for identifying a mutation in a hepadnavirus nucleic acid that confers resistance to an anti-hepadnavirus drug are also provided.
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