Fusions of cytokines and tumor targeting proteins
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United States of America Patent
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Issued Date -
Apr 7, 2005
app pub date -
Aug 9, 2004
filing date -
Apr 30, 2002
priority date (Note) -
Abandoned
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Abstract
A conjugate of a cytokine and a tumor targeting moiety (TTM) with the provisos that when cytokine is TNF-.alpha., TNF-.beta. or IFN-.gamma., the TTM is other than a CD13 ligant; when the cytokine is IL-12, the TTM is other than an antiboy to fibronectin; when the cytokine is TNF, the TTM is other than an antibody to the transferrin receptor, and when the cytokine is TNF, IFN-.gamma., or IL-2 the antibody is other than an antibody to the TAG72 antigen.
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