Phosphorothioate antisense heparanase oligonucleotides
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United States of America Patent
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app pub date -
Sep 10, 2004
filing date -
Jul 5, 2001
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Abstract
The present invention provides antisense phosphorothioate oligonucleotides that specifically inhibit the translation of heparanase. The invention also provides various methods of reducing angiogenesis and metastasis of tumors in a subject using said antisense phosphorothioate oligonucleotides. Finally the invention provides pharmaceutical compositions comprising the said antisense phosphorothioate oligonucleotides as active ingredients.
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