Adenoviral vector system
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United States of America Patent
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Issued Date -
Mar 10, 2005
app pub date -
Sep 29, 2004
filing date -
Oct 4, 2001
priority date (Note) -
Abandoned
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Abstract
The invention relates to an adenoviral vector on the base of human group B adenoviruses, specially of the subtype 11 containing as per invention heterologous elements, inverted terminal repeats (ITRs) in combination with the respective packaging signal of a different serotype virus, preferably of a type B virus. A heterologous promoter, preferably the SV40 promoter is contained and positioned between the packaging signal and the natural position for protein IX in the viral vector. This vector may be additionally deleted in reading frames of the regions E1, E2, E3 or E4. The invention also describes the use of this viral vector for the production of a high capacity vectors based on adenovirus 11, in which the only adenoviral sequences are ITRs and packaging signal and which contains human genomic stuffer sequences. Moreover, cell lines for the amplification of these viral vectors and application of the vectors in medicine are described.
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