Peptide beta-strand mimics based on 1,2-dihydro-3(6H)-pyridinone
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United States of America Patent
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Issued Date -
Feb 24, 2005
app pub date -
Sep 29, 2004
filing date -
Jun 5, 2001
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Abandoned
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Abstract
Peptide analogs formed by replacing one or more, but not all, amino acids of a peptide chain with 1,2-dihydro-3(6H)-pyridinone, display an unusually strong tendency to assume a .beta.-strand conformation and to enter into .beta.-sheet-like interactions with peptides and other peptide analogs that engage in .beta.-sheet-like interactions with peptides. The peptide analogs of this invention therefore have utility has .beta.-strand mimics offering advantages over native peptides as well as .beta.-strand mimics of the prior art.
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