Quinazolinone derivative
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United States of America Patent
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Issued Date -
Feb 24, 2005
app pub date -
Jun 17, 2004
filing date -
Dec 24, 2001
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Abandoned
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Abstract
A quinazolinone derivatives having poly (adenosine 5'-diphospho-ribose) polymerase (PARP) inhibitory activity represented by the formula (I): wherein R.sup.1 is substituted cyclic amino groups or optionally substituted amino group, R.sup.2 is substituent, n means an integer of 0 to 4, and L.sup.1 is (1) cyclo (lower) alkylene, (2) cyclo (lower) alkenylene, (3) diradical of saturated- or unsaturated monocyclic group with one or more nitrogen atom(s), which is obtained after removal of one hydrogen atom from said monocyclic group, or (4) --N(R.sup.3)--L.sup.2--(wherein R.sup.3 is hydrogen or lower alkyl, and L.sup.2 is lower alkylene or lower alkenylene), or its prodrug, or a salt thereof. 1
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