Methods for the identification of inhibitors of mannosyltransferase as antibiotics
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United States of America Patent
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Issued Date -
Feb 24, 2005
app pub date -
Jun 23, 2004
filing date -
Jun 24, 2003
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Abstract
The present inventors have discovered that mannosyltransferase is essential for normal fungal growth and pathogenicity. Specifically, the inhibition of mannosyltransferase gene expression in fungi results in drastically reduced growth and pathogenicity. Thus, mannosyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit mannosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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