Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
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United States of America Patent
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Issued Date -
Feb 24, 2005
app pub date -
Oct 21, 2004
filing date -
Dec 28, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol and an effective amount of an antioxidant. In one embodiment, the formulation also contains a tonicity modifier. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. Advantageously, the formulations can be prepared without the use of harmful co-solvents or surfactants, and are stable at room temperature over extended periods of time.
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