Method for identifying novel transcriptional regulatory proteins
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United States of America Patent
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Issued Date -
Feb 17, 2005
app pub date -
Mar 27, 2002
filing date -
Nov 7, 1998
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Abandoned
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Abstract
A method for identifying transcriptional regulatory proteins that modulate the transcription of a gene of interest is disclosed. In one embodiment, the method comprises introducing into a cell a nucleic acid molecule comprising three central components: 1) a polynucleotide (e.g., DNA) encoding a transcriptional regulatory protein; 2) an indicator gene which is responsive to, e.g., under the transcriptional control of, the gene regulatory sequences of a gene of interest which bind to the transcriptional regulatory protein; and 3) a selectable marker gene. The transcriptional regulatory protein binds to the gene regulatory sequences and either activates or inhibits transcription. A protein is identified as a modulator of the transcription of the gene of interest by detecting a signal generated by the indicator gene.
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