Methods for the identification of inhibitors of ornithine carbamoyltransferase as antibiotics
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United States of America Patent
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Issued Date -
Jan 27, 2005
app pub date -
May 20, 2004
filing date -
May 15, 2003
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Abstract
The present inventors have discovered that ornithine carbamoyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of ornithine carbamoyltransferase gene expression in fungi eliminates pathogenicity. Thus, ornithine carbamoyltransferase is useful as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit ornithine carbamoyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.
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