Aggregate-free protein compositions and methods of preparing same
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United States of America Patent
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Issued Date -
Jan 20, 2005
app pub date -
Aug 30, 2004
filing date -
Aug 6, 1998
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Abstract
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
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