Nitroreductase enzymes
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United States of America Patent
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Issued Date -
Jan 20, 2005
app pub date -
Sep 1, 2004
filing date -
Aug 21, 2001
priority date (Note) -
Abandoned
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Abstract
Improved nitroreductase enzymes, particularly for use as prodrug converting enzymes are provided. In particular, single and double mutants of the E. coli NFSB nitroreductase, having improved properties for the activation of the prodrug CB 1954 for use in gene therapy are disclosed.
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