Antibody affinity engineering by serial epitope-guided complementarity replacement
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United States of America Patent
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Issued Date -
Jan 13, 2005
app pub date -
Feb 13, 2004
filing date -
Feb 13, 2003
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Abandoned
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Abstract
This invention provides for a novel means for obtaining human idiologs for any non-human antibody to any target by epitope guided replacement of variable regions using competitive cell-based methods in which the competitor can be either the reference antibody or a ligand that binds to the same epitope on the target as the reference antibody.
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