Long lasting natriuretic peptide derivatives
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United States of America Patent
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Issued Date -
Dec 30, 2004
app pub date -
Sep 8, 2003
filing date -
Jul 31, 2002
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Abstract
This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardio-vascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.
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