Methods and compositions for desensitisation

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United States of America Patent

SERIAL NO

10809689

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a method of desensitising a patient to a polypeptide allergen the method comprising administering to the patient a peptide derived from the allergen wherein restriction to a MHC Class II molecule possessed by the patient can be demonstrated by the peptide and the peptide is able to induce a late phase response in an individual who possesses the said MHC Class II molecule. A composition comprising a plurality of peptides derived from a polypeptide allergen wherein for at least one of the peptides in the composition restriction to a MHC Class II molecule can be demonstrated, and the composition is able to induce a late phase response in an individual possessing the given MHC Class II moleculeis also provided. The invention also relates to a method of selecting a peptide for use as an immunotherapeutic agent for desensitising a patient to a polypeptide allergen capable of eliciting an allergic response in the patient.

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Patent Owner(s)

Patent OwnerAddress
CIRCASSIA LIMITEDOXFORD OX4 4GA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kay, Anthoney Barrington London, GB 1 5
Larche, Mark Surrey, London, GB 25 148

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