Remedies for dry eye and diseases associated with dry eye
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United States of America Patent
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Dec 2, 2008
Grant Date -
Dec 23, 2004
app pub date -
Nov 5, 2002
filing date -
Nov 6, 2001
priority date (Note) -
Expired
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Abstract
Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the general formula (I): H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X.sub.1-Gln-X.s-ub.2-Ala-Val-X.sub.3-X.sub.4-Tyr-Leu-X.sub.5-X.sub.6(SEQ ID NOS: 26-36) (I) wherein X.sub.1, X.sub.3 and X.sub.4 represent Lys or Arg, respectively; X.sub.2 represents Met, Leu or nLeu; X.sub.5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu(SEQ ID NO: 37) or Asn-Ser-Ile-Leu-Asn-X.sub.7(SEQ ID NOS: 38-43) (wherein X.sub.7 represents a chemical bond, Gly, etc.); and X.sub.6 represents --OH or --NH.sub.2, or pharmaceutically acceptable salts thereof:.
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