Compositions for oral administration of camptothecin and its analogs
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
N/A
Issued Date -
Dec 23, 2004
app pub date -
Jun 18, 2003
filing date -
Jun 18, 2003
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
Pharmaceutical compositions are provided which comprise a lactone form of camptothecin, or a lactone form analog thereof that is effective for controlling abnormal cell proliferation; and at least one amphiphilic block copolymer that, upon oral administration to a patient, increases oral bioavailability of the lactone form significantly more than that of a directly related carboxylate form of the camptothecin or analog thereof. Compositions are also provided that further comprise at least one bioadhesive polymer that protects a closed alpha-hydroxy lactone structure of the lactone form of camptothecin or analog thereof, and provides a controlled release of the lactone form of camptothecin or lactone form analog thereof, in GI, upon oral administration to a patient. Methods are described for the prevention and/or treatment of a condition related to abnormal cell proliferation comprising orally administering to a patient in need of thereof an effective amount of a composition of the present invention.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully