Process for the preparation of nitrile compounds
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United States of America Patent
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N/A
Issued Date -
Dec 16, 2004
app pub date -
Jul 19, 2004
filing date -
Jul 3, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A process is provided for the preparation of a compound of Formula (1) 1 wherein: R.sup.1 is H, optionally substituted acyl, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl: R.sup.2 and R.sup.3 each independently are H or a hydroxy protecting group; comprising the steps: (a) reacting a compound of Formula (2) 2 in a solvent in the presence of a base with a compound of formula R.sup.4SO.sub.2X to give a compound of Formula (3); 3 wherein: R.sup.4 is an optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl group; and X is halogen: and (b) reacting the compound of Formula (3) with a cyanide source in the presence of a phase transfer catalyst.
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