Compounds and methods for modulating beta-catenin mediated gene expression
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United States of America Patent
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app pub date -
Oct 14, 2003
filing date -
Apr 21, 1999
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Abstract
Modulating agents for inhibiting .beta.-catenin mediated gene expression are provided. The modulating agents comprise one or more of: (1) the peptide sequence LXXLL (SEQ ID NO:1); or (2) a peptide analogue or peptidomimetic thereof. Methods for using such modulating agents for modulating .beta.-catenin mediated gene expression and cellular differentiation in a variety of contexts (e.g., for modulating hair growth or treating cancer or Alzheimer's disease) are provided.
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