Biochemical test for identifying pregnancies with Down's syndrome fetus
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United States of America Patent
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Jan 1, 2008
Grant Date -
Dec 16, 2004
app pub date -
Jun 7, 2004
filing date -
Jun 10, 2003
priority date (Note) -
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Abstract
The invention provides prenatal screening methods for Down's syndrome. Specifically, the methods of the invention comprise determining the amount of hyperglycosylated human chorionic gonadotropin (hCG) charge isoforms in a biological sample from a pregnant woman and comparing the amount of highly acidic and less acidic isoforms with those found in a sample taken from a pregnant woman carrying a normal fetus. The methods of the invention can be employed during any stage of pregnancy.
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