Transgenic flies expressing Abeta42-dutch
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United States of America Patent
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Issued Date -
Dec 9, 2004
app pub date -
May 25, 2004
filing date -
Oct 21, 2003
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Abstract
The present invention discloses a transgenic fly that expresses the Dutch mutant version of the human A.beta.42 peptide of human amyloid-.beta. precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human A.beta.42.sub.Dutch peptide of human amyloid-.beta. precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
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