Biomaterials for nerve reconstruction and process for producing the same
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United States of America Patent
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Issued Date -
Dec 9, 2004
app pub date -
May 19, 2004
filing date -
Jun 14, 2001
priority date (Note) -
Abandoned
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Abstract
Disclosed is a biomaterial for nerve reconstruction, which comprises chitin or chitosan with a surface modified by a laminin fragment having an amino acid sequence of YIGSR or IKVAV. This biomaterial is produced, for example, by introducing a carboxyl group onto the surface of a substrate consisting of chitin or chitosan, immersing the substrate into an aqueous solution of a carboxyl-group activating reagent to activate the introduced carboxyl group, immobilizing a molecule having a thiol group to the carboxyl group, reacting the thiol group with a thiol-group activating reagent to form an S--S bond so as to activate the thiol group immobilized to the carboxyl group, and immersing the substrate into a phosphate buffer solution which contains a laminin fragment having an amino acid sequence of YIGSR or IKVAV, to cause a disulfide exchange reaction between a thiol group at the terminal end of the laminin fragment and the previously formed S--S bond so as to immobilize the laminin fragment to the substrate while protecting the active site of the laminin fragment.
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