Enhanced gene expression using vectors
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United States of America Patent
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Issued Date -
Dec 9, 2004
app pub date -
Jul 27, 2004
filing date -
Sep 14, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
There is described a vector able to express a transgene under the control of a promoter, the duration of expression being enhanced by the exposure of the vector to cytomegalovirus pp71 or a homologue thereof. Usually the vector will be a viral vector and Herpesvirus vectors are preferred. Suitable cytomegalovirus pp71 proteins include, but are not limited to, mouse, rat, chimpanzee, simian, equine and guinea pig pp71 proteins, but human pp71 is preferred. The vector may itself include the gene for expression of cytomegalovirus pp71.
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