DR5 gene promoter and siah-1 gene promoter
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United States of America Patent
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Issued Date -
Dec 9, 2004
app pub date -
Apr 2, 2004
filing date -
Oct 4, 2001
priority date (Note) -
Abandoned
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Abstract
The inventors discovered for the first time the nucleotide sequence of the human DR5 gene promoter, the nucleotide sequence of the human Siah-1 gene promoter and what appear to be the core promoter regions thereof. The present invention further provides a screening method for substances which regulate promoter activity, comprising a step of bringing a test substance into contact with cells holding a vector which comprises this DNA together with a reporter gene ligated expressibly to this DNA, and a step of detecting changes in the expressed amount of the reporter gene due to contact with the test substance. This screening method is a method of very efficiently selecting anti-cancer drugs and the like.
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