Isolation of cells from neural cell populations using antibodies to fa1/dlk1
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United States of America Patent
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app pub date -
Feb 23, 2004
filing date -
Aug 24, 2001
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Abandoned
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Abstract
The present invention relates to the use of antibodies recognising Fetal Antigen-1 (FA1/dlk1) for the detection and isolation of cell subpopulations from neural cell populations, in particular from cell populations from the central nervous system. In one embodiment, the dopaminergic neurons in the Substantia nigra pars compacta are detected and separated from other cell populations in this region of the brain. In another embodiment, neural stem and progenitor cells are isolated from other more committed cells in the CNS. The isolated cells may be used for transplantation, drug screening, production of cell type specific antibodies, and gene discovery.
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