Serine protease inhibitors compromising a hydrogen-bond acceptor
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United States of America Patent
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Issued Date -
Nov 25, 2004
app pub date -
Dec 18, 2003
filing date -
Jan 20, 2001
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Abstract
Compounds, useful as protease inhibitors, of the formula (I): where: Ar is a ring or ring system, for example a benzene ring, and may be substituted by one or more moieties in addition to X and LJ; X is a functional group which is a hydrogen-bond acceptor, e.g. a nitro or boronate group BY.sup.1Y.sup.2; L is a linker, most preferably (CR.sup.5R.sup.6)--S--; J is a moiety containing a basic nitrogen atom but not containing an amino acid residue, preferably amidino, guanidine, amino carboxamido, hydroxylamino, or imidazolyl, or an N-substituted analogue thereof.
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