Immune reactivity to expressed activated oncogenes for diagnosis and treatment of malignancy
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United States of America Patent
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Sep 24, 2003
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Jan 26, 1990
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Abstract
Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of immunocomplexes formed between the protein expression product and antibodies in body fluid, allows the diagnosis of the presence of a malignancy. The present invention also discloses methods and compositions for treating a malignancy.
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