Importance

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Abstract

It is intended to provide an antigen specific to Corynebacterium diphtheriae which is usable in developing vaccines for protecting/preventing infection with diphtheria. A gene encoding the following protein (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO:1 as described below:1 (SEQ ID NO:1) M F R R S L A S L A A V A V I S G V V V A P A N A V T V T V N N M T C T I K L T P E E T N F I P L S S P V M L T K E K A A F L K N Q Y G E T Q L S A L D A E I K K K E K E L T E L E P N A A G R E M L T S E L K E K K K R F T A N K K F S D A L D A C I A G E N Y D S S K P N G P K D P N G P K K P G D S D Q S G G S E K P N G P K D P G G S E K P N D P K H P E V E R A L P S T N G A V I G A I V A V L G I L A A A L P V I K S I L R A L L P; and (b) a protein comprising an amino acid sequence derived from the amino acid (a) by deletion, substitution or addition of one to several amino acids and having a C. diphtheriae antigenic activity.

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First Claim