Protease resistant ti-growth hormone releasing hormone
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United States of America Patent
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Issued Date -
Sep 30, 2004
app pub date -
Aug 21, 2002
filing date -
Jul 26, 1999
priority date (Note) -
Abandoned
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Abstract
One aspect of the current invention is a composition for a modified growth hormone releasing hormone ('GHRH') or functional biological equivalent thereof. Another aspect of the current invention includes a nucleic acid molecule that encodes the modified GHRH or functional biological equivalent. The modified GHRH can be defined as a biologically active polypeptide that was engineered to contain a distinct amino acid sequence while simultaneously having similar or improved biologically activity when compared to a wild-type GHRH ('wt-GHRH') polypeptide. Another aspect of the current invention includes a method for delivering the composition of this invention to a subject, wherein the modified GHRH increases the level of growth hormone ('GH') secretion in a subject. The preferred subject is a human or domesticated animal. Additionally, the modified GHRH composition is resistant to degradation when compared to the wt-GHRH.
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