Nucleoside vaccine adjuvants
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Sep 30, 2004
app pub date -
May 7, 2004
filing date -
Jun 15, 2001
priority date (Note) -
Abandoned
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Abstract
Contemplated methods and compositions include a pharmacological composition comprising an antigen and a nucleoside adjuvant that modulates the balance between Type 1 response and Type 2 response in a lymphocyte, wherein the nucleoside is not an 8-substituted guanine nucleoside. In preferred aspects, contemplated adjuvants stimulate Type 1 response and thereby increase a T-cell response, while contemplated adjuvants may also stimulate a Type 2 response and thereby increase a B-cell response. Preferred adjuvants may further comprise a CpG-dinucleotide and/or a CpG-containing oligonucleotide in a synergistic amount.
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