Complexation of rna, especially ribozymes, with polyrthylenimines for the stabilization and cellular introduction thereof
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United States of America Patent
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Issued Date -
Aug 26, 2004
app pub date -
Feb 21, 2003
filing date -
Dec 14, 1999
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Abandoned
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Abstract
The invention relates to the complexation of RNA with optionally modified polyethylenimines for extracellular and intracellularin vitro and in vivo stabiliztion thereof and for cellular introduction of the complexed RNA in cells. The invention also relates to chemically modified or non-modified, natural or synthetic ribozymes complexes and polyethylenimine (PEI) having any chain length, molar mass and degree of branching, which is chemically modified or non-chemically modified. The invention further relates to the production of complexes and to the use thereof in the protection of RNA against enzymatic and non-enzymatic degradation and their reception in vitro or in vivo in cells. The biological activity of the ribozymes remains intact.
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