Monoclonal antibodies specific for latent antithrombin III and the use thereof
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United States of America Patent
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Issued Date -
Aug 19, 2004
app pub date -
Feb 19, 2003
filing date -
Feb 19, 2003
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Abstract
The present invention provides antibodies that are specific for the latent or locked form of antithrombin III (AT III). The antibodies have a specificity for latent antithrombin III (1-AT III) that is higher than the specificity for natural AT III. The invention also provides methods of making and 1-AT III. It further provides methods of detecting and quantitating 1-AT III in biological samples.
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