Methods for producing and improving therapeutic potency of binding polypeptides
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United States of America Patent
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Issued Date -
Aug 19, 2004
app pub date -
Feb 26, 2004
filing date -
Oct 30, 2001
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Abandoned
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Abstract
The invention provides a binding polypeptide, or functional fragment thereof, comprising a k.sub.on of at least about 9.times.10.sup.7 M.sup.-1s.sup.-1 for associating with a ligand and having therapeutic potency. The invention also provides a method of determining the therapeutic potency of a binding polypeptide. The methods consist of (a) contacting a binding polypeptide with a ligand; (b) measuring association rate for binding between the binding polypeptide and the ligand, and (c) comparing the association rate for the binding polypeptide to an association rate for a therapeutic control, the relative association rate for the binding polypeptide compared to the association rate for the therapeutic control indicating that the binding polypeptide will exhibit a difference in therapeutic potency correlative with the difference between the association rates.
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