Preparation of substituted quinazolines
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United States of America Patent
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Issued Date -
Aug 12, 2004
app pub date -
Feb 4, 2004
filing date -
Feb 5, 2003
priority date (Note) -
Abandoned
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Abstract
Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)--quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazo-line side products. 1
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