Method for monitoring the rate of t-cells recently emigrated from the thymus
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United States of America Patent
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Issued Date -
Aug 12, 2004
app pub date -
Dec 23, 2003
filing date -
Jun 25, 2001
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Abstract
The chemokine receptor CCR9 is reported to be predominantly expressed by thymocytes as well as by circulating gut-homing and resident T cells in the small intestinal mucosa. Its ligand TECK (thymus-expressed chemokine) is produced by thymic and small intestinal epithelium. Here we report that the relative fraction of circulating CCR9.sup.+ naive T cells (mostly CD4+) declines with age, from approximately 15% of all T cells at birth to around 1% in adults. The proportion of CCR9.sup.+ T cells negative for the classical gut homing marker .alpha.4.beta.7, was much higher in childhood than in adults. Therefore, circulating CD3.sup.+CD45RA.sup.+CCR9.sup.+ cells have most likely left the thymus quite recently. Establishing a phenotypic marker for recent thymic emigrants may provide a powerful tool in the clinical assessment and follow-up after hematopoietic stem cell transplantation and during antiretroviral treatment of HIV-infected patients.
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