Lipid-drug complexes in reversed liquid and liquid crystalline phases
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United States of America Patent
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Issued Date -
Aug 12, 2004
app pub date -
Aug 6, 2003
filing date -
Aug 6, 2002
priority date (Note) -
Abandoned
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Abstract
A pharmaceutical is formulated to enable enhanced delivery across membrane barriers, permit solubilization, protect compounds from deactivation by thiol containing compounds in the body, and allow retention of the drug during transport to a desired site of activity. The pharmaceutical includes a complex of two moieties where at least one is pharmaceutically active and is larger than a single atom in size, and the second moiety, when combined with a cationic or anionic counterion forms either a pharmaceutically acceptable anionic or cationic surfactant or a pharmaceutically acceptable salt that has an octanol water partition coefficient of greater than about 100.
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