Targeted adenoviral vector displaying immunoglobulin-binding domain and uses thereof
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United States of America Patent
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Issued Date -
Jul 29, 2004
app pub date -
Jul 22, 2003
filing date -
Jul 22, 2002
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Abandoned
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Abstract
The present invention provides a targeted recombinant adenovirus vector expressing a fiber protein modified by insertion of an immunoglobulin-binding domain that can crosslink to a fusion protein comprising a targeting ligand and an immunoglobulin Fc domain. Interaction between the immunoglobulin-binding domain and the Fc domain results in a targeted vector::ligand complex, thereby targeting the adenovirus vector to a cell that expresses a cell surface molecule that binds to said targeting ligand.
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