MHC tetramers
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United States of America Patent
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Issued Date -
Jul 15, 2004
app pub date -
Oct 9, 2003
filing date -
Apr 10, 2001
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Abandoned
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Abstract
The invention relates to MHC tetramer fusion proteins, MHC monomer fusion proteins, DNA encoding a MHC fusion protein as well as RNA yielding after transcription a MHC monomer fusion protein. Furthermore, the invention discloses the use of a DsRed protein as an agent for the tetramerization of MHC molecules, methods for the preparation of fusion proteins containing MHC and DsRed, and methods for the preparation of MHC tetramers. Moreover, the invention describes methods for the examination of an antigen-specific cellular immune response, particularly for the detection of T lymphocytes carrying specific T cell receptors on their surfaces, the uses of the MHC monomers and tetramers prepared according to the invention as well as test systems containing the MHC monomers or MHC tetramers according to the invention.
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