Antibiotics for the treatment of infections in acidic environments
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United States of America Patent
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Issued Date -
Jul 8, 2004
app pub date -
Oct 22, 2003
filing date -
Oct 23, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological conditions, for the treatment of bacterial infections in acidic environments (pH<7.0). The activity of these compounds is strongly increased at even slightly acidic conditions what makes them especially interesting for the treatment of infections in abscesses or inflamed tissues.
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