HIV-like particles and the use thereof
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United States of America Patent
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Apr 14, 2009
Grant Date -
Jul 8, 2004
app pub date -
Jan 8, 2002
filing date -
Jan 8, 2001
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Abstract
Disclosed are alphavirus-based expression vectors expressing env, gag, pro, and/or pol genes of HIV-1, their transcripts, and transformed host cells. The present invention describes the expression of the Gag, Env, Pol, and/or Pro Proteins using the above expression vectors, and HIV-like particles (HIVLPs) composed of the above recombinant proteins. The virus-like particles (VLPs) of the present invention, as the mature and infective particles, are very useful as an antigen for a diagnostic kit for HIV infection as well as for a vaccine composition for prevention of HIV infection.
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