Methods for treating and preventing Gram-positive bacteremias
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United States of America Patent
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Issued Date -
Jul 1, 2004
app pub date -
Sep 4, 2003
filing date -
Sep 6, 2002
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods and compositions useful for preventing a bacteremia by administering ramoplanin to decolonize the intestinal tract of a patient. Also disclosed are methods for treating bacteremias using combination therapy directed both toward treating the infection as well as decolonizing the intestinal tract of the patient. The invention is particularly useful against antibiotic-resistant Gram-positive bacteria, such as vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), glycopeptide intermediary susceptible Staphylococcus aureus (GISA), and coagulase-negative staphylococci.
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