Ultrasound contrast agents containing microbubbles of perfluoracarbon gasses
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United States of America Patent
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Issued Date -
Jul 1, 2004
app pub date -
Apr 9, 2003
filing date -
Sep 17, 1991
priority date (Note) -
Abandoned
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Abstract
Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or 'microbubbles,' comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of microbubbles comprised of the gas.
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