Uroguanylin and cyclooxygenase-2 inhibitor combinations for inhibition of intestinal cancer
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United States of America Patent
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Issued Date -
Jun 24, 2004
app pub date -
Jan 21, 2004
filing date -
Feb 4, 2002
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Abandoned
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Abstract
Disclosed is a method of retarding the development of polyps and prevention, inhibition and treatment of cancer in the intestine of a subject by administration of a composition comprising a peptide with the active domain of uroguanylin or any agonist peptide or compound binding to the guanylate cyclase receptor GC-C in the intestine in combination with a naturally occurring, derived from a naturally occurring, or a chemically synthesized cycloogenase-2 inhibitor, preferably a selective cyclooxygenase-2 inhibitor.
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