Compounds which inhibit beta-secretase activity and methods of use thereof
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United States of America Patent
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Issued Date -
Jun 24, 2004
app pub date -
Oct 23, 2002
filing date -
Dec 28, 2000
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Abandoned
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Abstract
Compounds inhibit memapsin 2 .beta.-secretase activity and selectively inhibit memapsin 2 .beta.-secretase activity relative to memapsin 1 .beta.-secretase activity. The compounds are employed in methods to inhibit memapsin 2 .beta.-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a .beta.-secretase site of a .beta.amyloid precursor protein and to decrease .beta.-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
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