Oligonucleotides and methods using same for treating cox-ll associated diseases
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Issued Date -
Jun 10, 2004
app pub date -
Dec 10, 2002
filing date -
Dec 10, 2002
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Abstract
A small interfering duplex oligonucleotide comprising a 15 to 30 base pair sequence being at least 90 % identical to a contiguous nucleic acid sequence of COX-II, as determined using the GCG BestFit software of the Wisconsin sequence analysis package, utilizing the Smith and Waterman algorithm, where gap weight equals 50, length weight equals 3, average match equals 10 and average mismatch equals -9.
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